Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 20/20 | 1.00 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.67 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30029406 | 0.90 | MAP3K5 (0.81) | MAP3K5 | |
| SCHEMBL28901803 | 0.90 | MAP3K5 (0.81) | MAP3K5 | |
| SCHEMBL20522758 | 0.88 | MAP3K5 (0.80) | MAP3K5 | |
| SCHEMBL20878411 | 0.87 | MAP3K5 (0.84) | MAP3K5MAP3K7MAP3K6 | |
| SCHEMBL20571165 | 0.87 | MAP3K5 (0.77) | MAP3K5 | |
| SCHEMBL28901811 | 0.87 | MAP3K5 (0.76) | MAP3K5 | |
| SCHEMBL29624559 | 0.87 | MAP3K5 (0.84) | MAP3K5 | |
| SCHEMBL20522986 | 0.86 | MAP3K5 (0.79) | MAP3K5 | |
| SCHEMBL23631287 | 0.86 | MAP3K5 (0.79) | MAP3K5MAP3K7MAP3K6 | |
| SCHEMBL20523188 | 0.86 | MAP3K5 (0.86) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253018-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253018-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | BAD, CASP1, BAX | MAP3K5 23/4885MAP3K7 32/4885MAP3K6 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.