Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | ALB | P02768 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | POLG | P54098 | 2/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17378541 | 1.00 | PDE3A (0.48) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL20879387 | 0.93 | LMNA (0.52) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL18877436 | 0.90 | PDE3A (0.49) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL22110711 | 0.89 | PDE3A (0.48) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL30997061 | 0.89 | PDE3A (0.48) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL25399556 | 0.89 | PDE3A (0.48) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL20879508 | 0.89 | PDE3A (0.48) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL25401300 | 0.88 | PDE3A (0.46) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL26793921 | 0.88 | PDE3A (0.46) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL25401505 | 0.87 | PDE3A (0.47) | PDE3ALMNACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466959-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen BioPharma, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |