Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20879769 | 0.79 | KDM4C (0.35) | PBRM1CHEK1AREPHX2EGLN2 | |
| SCHEMBL19062270 | 0.79 | CYP3A4 (0.34) | ARS1PR3 | |
| SCHEMBL18602334 | 0.79 | CHEK1 (0.32) | PBRM1CHEK1ARNSD2NSD3 | |
| SCHEMBL171647 | 0.79 | KDM4C (0.35) | PBRM1CHEK1AREPHX2EGLN2 | |
| SCHEMBL20963164 | 0.77 | ESR1 (0.35) | PBRM1CHEK1AREPHX2ESR1 | |
| SCHEMBL12251238 | 0.77 | EPHX2 (0.34) | PBRM1CHEK1AREPHX2 | |
| SCHEMBL19592313 | 0.76 | AR (0.32) | PBRM1CHEK1AREPHX2 | |
| SCHEMBL18599607 | 0.73 | ESR1 (0.33) | PBRM1AREPHX2ESR1ESR2 | |
| SCHEMBL1584837 | 0.72 | CHEK1 (0.36) | CHEK1EPHX2EGLN2S1PR1S1PR3 | |
| SCHEMBL104694 | 0.72 | PANK3 (0.39) | CHEK1AREPHX2EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |