Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171647 | 1.00 | KDM4C (0.35) | KDM4CEPHX2ARPIK3CDABL1 | |
| SCHEMBL20372862 | 0.84 | ALDH1A1 (0.43) | EPHX2ARPIK3CDABL1EGFR | |
| SCHEMBL12251238 | 0.83 | EPHX2 (0.34) | KDM4CEPHX2ARPIK3CDABL1 | |
| SCHEMBL18552809 | 0.81 | EPHX2 (0.37) | EPHX2ARPIK3CDABL1EGFR | |
| SCHEMBL20963164 | 0.80 | ESR1 (0.35) | EPHX2ARPIK3CDABL1EGFR | |
| SCHEMBL18599607 | 0.80 | ESR1 (0.33) | EPHX2ARPIK3CDABL1EGFR | |
| SCHEMBL104694 | 0.80 | PANK3 (0.39) | EPHX2ARPIK3CDABL1EGFR | |
| SCHEMBL20879770 | 0.79 | PBRM1 (0.33) | EPHX2ARPBRM1CHEK1EGLN2 | |
| SCHEMBL18602334 | 0.79 | CHEK1 (0.32) | EPHX2ARPIK3CDABL1EGFR | |
| SCHEMBL169697 | 0.79 | SMN1; SMN2 (0.36) | ARALDH1A1CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |