Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23020652 | 1.00 | HPGD (0.57) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL4817684 | 0.87 | HPGD (0.57) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL16521997 | 0.86 | HPGD (0.55) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL26478903 | 0.86 | HPGD (0.55) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL16521992 | 0.86 | HPGD (0.55) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL4817697 | 0.84 | HPGD (0.57) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL8321173 | 0.81 | TSHR (0.70) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL10353331 | 0.81 | TSHR (0.70) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL10353314 | 0.79 | TSHR (0.67) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL4964666 | 0.79 | KMT2A (0.67) | HPGDRECQLMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2596805-B1 | Prodrug comprising a drug-linker conjugate | ASCENDIS PHARMA AS (DK) | 2021-10-27 | — | — | EP | disclosed |
| EP-3050576-B1 | PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS | ASCENDIS PHARMA ENDOCRINOLOGY DIV A/S (DK) | 2021-03-31 | — | — | EP | disclosed |
| EP-2459220-B1 | BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS | ASCENDIS PHARMA AS (DK) | 2020-09-09 | — | — | EP | disclosed |
| EP-2741782-B1 | PROTEIN CARRIER-LINKED PRODRUGS | ASCENDIS PHARMA AS (DK) | 2020-05-06 | — | — | EP | disclosed |
| EP-2237799-B1 | PRODRUG COMPRISING A SELF-CLEAVABLE LINKER | ASCENDIS PHARMA AS (DK) | 2019-04-10 | — | — | EP | disclosed |