Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353314 | 0.94 | TSHR (0.67) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL8321173 | 0.92 | TSHR (0.70) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL10353331 | 0.92 | TSHR (0.70) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL25190021 | 0.90 | KMT2A (0.60) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL4387100 | 0.90 | KMT2A (0.60) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL13621106 | 0.87 | GAA (0.67) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL17055772 | 0.84 | KMT2A (0.55) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL17130350 | 0.84 | KMT2A (0.55) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL13006881 | 0.84 | GAA (0.64) | KMT2ATSHRMEN1GAASMN1; SMN2 | |
| SCHEMBL27314194 | 0.83 | PKM (0.53) | KMT2ATSHRMEN1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893581-A1 | SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES | Pfizer Limited (GB) | 2008-03-05 | — | — | EP | claimed |
| WO-2006134468-A1 | SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES | PFIZER LIMITED (GB) | 2006-12-21 | — | — | WO | claimed |