Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923983 | 0.88 | AKR1C3 (0.70) | AKR1C3ALDH1A1LMNAMAPTGAA | |
| SCHEMBL10288811 | 0.83 | PANK3 (0.58) | ALDH1A1SMN1; SMN2LMNAHTTHPGD | |
| SCHEMBL10169298 | 0.83 | MAPT (0.71) | ALDH1A1SMN1; SMN2LMNAHTTHPGD | |
| SCHEMBL23544884 | 0.82 | PANK3 (0.57) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL22854086 | 0.82 | PANK3 (0.57) | AKR1C3ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL4985735 | 0.81 | AKR1C3 (0.68) | AKR1C3ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL22542072 | 0.81 | AKR1C3 (0.76) | AKR1C3ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL20884954 | 0.81 | AKR1C3 (0.58) | AKR1C3ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL20883570 | 0.81 | PANK3 (0.56) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL23544877 | 0.81 | PANK3 (0.56) | ALDH1A1SMN1; SMN2LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807994-B2 | Heterocyclic compounds and uses thereof | NUVATION BIO INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190106436-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2019-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106436-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | WEE1, WEE2, NME1 | AKR1C3 3590/4885ALDH1A1 2869/4885SMN1; SMN2 4343/4885 |
| US-10807994-B2 | Heterocyclic compounds and uses thereof | WEE1, WEE2, CCNE1 | AKR1C3 2214/4885ALDH1A1 1113/4885SMN1; SMN2 4150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.