Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288811 | 0.85 | PANK3 (0.58) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL10169298 | 0.85 | MAPT (0.71) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL23544884 | 0.83 | PANK3 (0.57) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL5725441 | 0.82 | GFER (0.71) | SMN1; SMN2ALDH1A1MAPTMAPK1TP53 | |
| SCHEMBL25839459 | 0.82 | PANK3 (0.56) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL20883565 | 0.82 | AKR1C3 (0.67) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL23544877 | 0.82 | PANK3 (0.56) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL20883570 | 0.82 | PANK3 (0.56) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL20251137 | 0.82 | MAPT (0.51) | PANK3SMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL3174172 | 0.81 | CHIA (0.69) | SMN1; SMN2ALDH1A1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261294-A1 | NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | MANKIND PHARMA LTD. (IN) | 2020-12-30 | — | — | WO | disclosed |