Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20885696 | 0.91 | MAP4K4 (0.52) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885652 | 0.87 | MAP4K4 (0.55) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885881 | 0.86 | MALT1 (0.55) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885643 | 0.85 | MAP4K4 (0.53) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885799 | 0.84 | MAP4K4 (0.52) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885808 | 0.84 | MAP4K4 (0.55) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885879 | 0.84 | KDM1A (0.53) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885658 | 0.83 | MAP4K4 (0.51) | MAP4K4KDM1AHDAC1MALT1KDM4E | |
| SCHEMBL20885604 | 0.83 | RARB (0.52) | MAP4K4KDM1AHDAC1MALT1MEN1 | |
| SCHEMBL20885687 | 0.82 | KDM1A (0.52) | MAP4K4KDM1AHDAC1MALT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752596-B2 | Nitrogen-containing heteroaryl compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2020-08-25 | — | — | US | disclosed |
| US-20190152926-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2019-05-23 | — | — | US | disclosed |
| WO-2019069973-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND, AND PHARMACEUTICAL USE THEREOF | 日本たばこ産業株式会社 | 2019-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10752596-B2 | Nitrogen-containing heteroaryl compound and pharmaceutical use thereof | SLC2A9, SLC6A19, SLC5A2 | MAP4K4 4128/4885KDM1A 3547/4885HDAC1 2040/4885 |
| US-20190152926-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUND AND PHARMACEUTICAL USE THEREOF | SLC2A9, SLC6A19, SLC5A2 | MAP4K4 4128/4885KDM1A 3547/4885HDAC1 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.