SLC6A19

Sodium-dependent neutral amino acid transporter B(0)AT1

723 patent compounds predicted against SLC6A19, 560 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cinromide (SCHEMBL35055)	1.00	1/20
Cinromide (SCHEMBL35056)	1.00	1/20
SCHEMBL27735722	0.75	1/20
SCHEMBL11257541	0.72	1/20
SCHEMBL11257542	0.72	1/20
SCHEMBL11257545	0.72	1/20
SCHEMBL8740836	0.71	1/20
SCHEMBL8740837	0.71	1/20
SCHEMBL8740838	0.71	1/20
SCHEMBL12426058	0.69	1/20
SCHEMBL14244643	0.69	1/20
SCHEMBL31482396	0.69	1/20
SCHEMBL29282139	0.69	1/20
SCHEMBL30913220	0.69	1/20
SCHEMBL28891943	0.68	1/20
SCHEMBL6835379	0.68	1/20
SCHEMBL975477	0.67	1/20
SCHEMBL975479	0.67	1/20
SCHEMBL9781847	0.67	1/20
SCHEMBL9781852	0.67	1/20

Germline variants in SLC6A19 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full SLC6A19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to SLC6A19 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)	PHASE4	COMPLETED
Effect of Age on the Renal Clearance of Adefovir	PHASE4	WITHDRAWN
Salt Loading and Thiazide Intervention Study	PHASE4	COMPLETED
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia	PHASE1/PHASE2	RECRUITING
Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®	PHASE1/PHASE2	COMPLETED
Study on Amino Acid Uptake in Brain Tumors	PHASE2	UNKNOWN
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer	EARLY_PHASE1	UNKNOWN
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy	nan	NOT_YET_RECRUITING
Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia	nan	COMPLETED
A Study of Cases with Abnormal Serum Ammonia in Neonate and Children Attending Assiut University Children Hospital	nan	NOT_YET_RECRUITING
Additional Dietary Large Neutral Amino Acids (LNAA) for Improved Symptoms in Adult Classical Phenylktonuria (PKU)	nan	UNKNOWN
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting	nan	UNKNOWN
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS	nan	COMPLETED
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers	nan	COMPLETED
Renal Transporters After Renal Transplantation	nan	UNKNOWN
Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs	nan	COMPLETED
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract	nan	COMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients	nan	UNKNOWN
Brain P-gp and Inflammation in People With Epilepsy	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
Fluorescence and Glioma Heterogeneity	nan	COMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SLC6A19 binder may also engage these)

Protein	Name	Similarity
Q5R6J1	—	1.000	Q5R6J1 →
Q9D687	—	1.000	Q9D687 →
Q2A865	—	1.000	Q2A865 →
P31649	—	1.000	P31649 →
Q9NP91	—	1.000	Q9NP91 →
SLC6A4	Sodium-dependent serotonin transporter	1.000	landscape →
Q62687	—	1.000	Q62687 →
Q8VDB9	—	1.000	Q8VDB9 →
P31646	—	1.000	P31646 →
P23977	—	1.000	P23977 →
P48057	—	1.000	P48057 →
Q61327	—	1.000	Q61327 →
O88575	—	1.000	O88575 →
O88576	—	0.999	O88576 →
P28570	—	0.999	P28570 →
P31661	—	0.999	P31661 →
B4JMC1	—	0.999	B4JMC1 →
SLC6A13	Sodium- and chloride-dependent GABA transporter 2	0.999	landscape →
P51143	—	0.999	P51143 →
Q8BG16	—	0.999	Q8BG16 →
SLC6A6	Sodium- and chloride-dependent taurine transporter	0.999	landscape →
P31652	—	0.998	P31652 →
Q9MZ34	—	0.998	Q9MZ34 →
Q9MYX0	—	0.998	Q9MYX0 →
A7Y2W8	—	0.998	A7Y2W8 →
Q9UN76	—	0.998	Q9UN76 →
P31651	—	0.998	P31651 →
Q9JMA9	—	0.998	Q9JMA9 →
SLC6A11	Sodium- and chloride-dependent GABA transporter 3	0.998	landscape →
P51905	—	0.998	P51905 →