Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 16/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1402045 | 1.00 | ADORA3 (0.57) | ADORA3ADORA2AADORA1PPARD | |
| SCHEMBL1402109 | 0.86 | ADORA2A (0.49) | ADORA3ADORA2AADORA1 | |
| SCHEMBL1402115 | 0.86 | ADORA2A (0.47) | ADORA3ADORA2AADORA1 | |
| SCHEMBL1402144 | 0.86 | ADORA3 (0.42) | ADORA3ADORA2AADORA1 | |
| SCHEMBL243106 | 0.85 | ADORA2A (0.41) | ADORA3ADORA2AADORA1 | |
| SCHEMBL1401998 | 0.84 | ADORA2A (0.42) | ADORA3ADORA2AADORA1 | |
| SCHEMBL1402064 | 0.84 | ADORA2A (0.42) | ADORA3ADORA2AADORA1 | |
| SCHEMBL3005772 | 0.84 | ADORA3 (0.40) | ADORA3ADORA2AADORA1 | |
| SCHEMBL1402099 | 0.83 | ADORA3 (0.43) | ADORA3ADORA2AADORA1 | |
| SCHEMBL242888 | 0.82 | ADORA2A (0.50) | ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163754-B2 | inflammatory or obstructive airways diseases; in combination with an antiinflammatory, bronchodilatory, antihistamine or anti-tussive; N-[4-(6-Amino-2-phenethylamino-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide | NOVARTIS AG (CH) | 2012-04-24 | — | — | US | disclosed |
| US-20080200483-A1 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists | NOVARTIS AG (CH) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200483-A1 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists | ADORA2A, ADORA1, ADORA3 | ADORA3 3/4885ADORA2A 1/4885ADORA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.