Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602086 | 0.76 | FGFR3 (0.46) | FGFR3KDRFLT3 | |
| SCHEMBL13337071 | 0.72 | FLT3 (0.38) | FGFR3KDRFLT3KDM4EALDH1A1 | |
| SCHEMBL3197111 | 0.71 | KDR (0.43) | KDRFLT3 | |
| SCHEMBL3177430 | 0.71 | FLT3 (0.46) | KDRFLT3 | |
| SCHEMBL1431511 | 0.70 | KDR (0.45) | FGFR3KDRFLT3 | |
| SCHEMBL1431367 | 0.69 | KDR (0.46) | FGFR3KDRFLT3 | |
| SCHEMBL601400 | 0.69 | KDR (0.51) | FGFR3KDRFLT3 | |
| SCHEMBL11925640 | 0.68 | KDR (0.46) | FGFR3KDRFLT3KDM4EALDH1A1 | |
| SCHEMBL532747 | 0.68 | ALDH1A1 (0.64) | KDM4EALDH1A1HSD17B10NPC1POLB | |
| SCHEMBL532352 | 0.68 | PIK3CA (0.41) | TP53CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300465-B1 | IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTEX THERAPEUTICS LTD (GB) | 2019-04-17 | — | — | EP | disclosed |