Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21016815 | 0.77 | HTR7 (0.37) | HTTHTR7ADORA2AADORA1ADORA3 | |
| SCHEMBL30476568 | 0.75 | GGPS1 (0.41) | HTTHTR7ADORA2AGBA1PDE5A | |
| SCHEMBL2312913 | 0.75 | GGPS1 (0.41) | HTTHTR7ADORA2AGBA1PDE5A | |
| SCHEMBL2315103 | 0.75 | AHR (0.58) | — | |
| SCHEMBL15028171 | 0.74 | TRPV1 (0.38) | HTTHTR7ADORA2AADORA1ADORA3 | |
| SCHEMBL23629395 | 0.68 | AHR (0.34) | HTTADORA2AGBA1CNR2 | |
| SCHEMBL30954755 | 0.68 | AHR (0.34) | HTTADORA2AGBA1CNR2 | |
| SCHEMBL29727544 | 0.68 | AHR (0.38) | HTTADORA2AADORA1ADORA3GBA1 | |
| SCHEMBL23991713 | 0.68 | AHR (0.38) | HTTADORA2AADORA1ADORA3GBA1 | |
| SCHEMBL19276304 | 0.67 | PIK3CA (0.38) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524604-A1 | EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2019-08-14 | — | — | EP | disclosed |
| EP-2350078-B1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2019-04-17 | — | — | EP | disclosed |