Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 6/20 | 0.49 |
| ▸ | BCHE | P06276 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597699 | 0.85 | ACHE (0.50) | ACHEMEN1KMT2ABACE1BCHE | |
| SCHEMBL13676574 | 0.83 | ACHE (0.57) | ACHEMEN1KMT2ABACE1BCHE | |
| SCHEMBL13676573 | 0.83 | ACHE (0.57) | ACHEMEN1KMT2ABACE1BCHE | |
| SCHEMBL13005299 | 0.83 | ACHE (0.57) | ACHEMEN1KMT2ABACE1BCHE | |
| SCHEMBL7775764 | 0.80 | ACHE (0.54) | ACHEBACE1BCHECYP1A2CYP3A4 | |
| SCHEMBL5980555 | 0.80 | ACHE (0.54) | ACHEBACE1BCHECYP1A2CYP3A4 | |
| SCHEMBL7775686 | 0.80 | ACHE (0.54) | ACHEBACE1BCHECYP1A2CYP3A4 | |
| SCHEMBL2676077 | 0.80 | ACHE (0.54) | ACHEMEN1KMT2ABACE1BCHE | |
| SCHEMBL2676079 | 0.80 | ACHE (0.54) | ACHEMEN1KMT2ABACE1BCHE | |
| SCHEMBL4884981 | 0.80 | ACHE (0.54) | ACHEMEN1KMT2ABACE1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970215-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND (DE) | 2019-04-17 | — | — | EP | disclosed |