Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175496 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1FAAHTGFBR1ACVR1 | |
| SCHEMBL12551119 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1FAAHLMNATDP1 | |
| SCHEMBL10001302 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1TGFBR1ACVR1LMNA | |
| SCHEMBL12551114 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL5886084 | 0.78 | KDM4E (0.65) | KDM4EALDH1A1FAAHCDK1CDK2 | |
| SCHEMBL1235260 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1FAAHTGFBR1ACVR1 | |
| SCHEMBL4563378 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1FAAHKDM5BPRMT5 | |
| SCHEMBL18945542 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1FAAHKDM5BPRMT5 | |
| SCHEMBL23701480 | 0.77 | HSP90AA1 (0.65) | KDM4EALDH1A1FAAHLMNAHSP90AA1 | |
| SCHEMBL10022346 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1KDM5BRORCLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019073251-A1 | LYSYL OXIDASE INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2019-04-18 | — | — | WO | disclosed |