SCHEMBL20908445

SCHEMBL20908445

O=c1[nH]cnc2c1ncn2[C@H]1C[C@@H]2OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c4ncn4ccnc54)[C@H](O)[C@@H]3OP(=O)(O)OC[C@H]2O1

nearest known ligand 0.72

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ STING1 Q86WV6 20/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20908476 0.94 STING1 (0.82) STING1
SCHEMBL20908500 0.93 STING1 (0.59) STING1
SCHEMBL24323071 0.92 STING1 (0.71) STING1
SCHEMBL24323072 0.88 STING1 (0.72) STING1
SCHEMBL20908440 0.88 STING1 (0.72) STING1
SCHEMBL20908833 0.86 STING1 (0.67) STING1
SCHEMBL24209548 0.86 STING1 (0.89) STING1
SCHEMBL23476764 0.85 STING1 (1.00) STING1
SCHEMBL31685488 0.85 STING1 (1.00) STING1
SCHEMBL29374900 0.85 STING1 (1.00) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019074887-A1 CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2019-04-18 — — WO disclosed
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