Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19484268 | 0.79 | SIGMAR1 (0.41) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL19480710 | 0.75 | SIGMAR1 (0.42) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL19477233 | 0.75 | SIGMAR1 (0.42) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL21984718 | 0.75 | SIGMAR1 (0.42) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| Hydrochloric Acid SCHEMBL28378836 | 0.74 | SIGMAR1 (0.41) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| Hydrochloric Acid SCHEMBL28378834 | 0.74 | SIGMAR1 (0.41) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL19479362 | 0.73 | SIGMAR1 (0.40) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL19479361 | 0.73 | SIGMAR1 (0.40) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL24468425 | 0.70 | PDE2A (0.44) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL31136292 | 0.70 | PDE2A (0.44) | SIGMAR1LMNAMAPTADRA2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392369-B2 | N-[(pyrimidinyloxy)propanyl]benzamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-27 | — | — | US | disclosed |
| US-20190112295-A1 | NOVEL N-[(PYRIMIDINYLOXY)PROPANYL]BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-04-18 | — | — | US | disclosed |
| US-9884854-B2 | N-[(pyrimidinylamino)propanyl]-and N[(pyrazinylamino)proppanyl]arylcarboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-06 | — | — | US | disclosed |
| US-20170298053-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N [(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GHBH (DE) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392369-B2 | N-[(pyrimidinyloxy)propanyl]benzamides | HCRTR1, HCRTR2, CNR1 | SIGMAR1 91/4885LMNA 2187/4885MAPT 1607/4885 |
| US-20190112295-A1 | NOVEL N-[(PYRIMIDINYLOXY)PROPANYL]BENZAMIDES | HCRTR1, HCRTR2, CNR1 | SIGMAR1 85/4885LMNA 2753/4885MAPT 1719/4885 |
| US-20170298053-A1 | NOVEL N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N [(PYRAZINYLAMINO)PROPANYL]ARYLCARBOXAMIDES | HCRTR2, HCRTR1, CNR1 | SIGMAR1 176/4885LMNA 1241/4885MAPT 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.