Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 16/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22594931 | 0.89 | PTPN11 (0.39) | PTPN11CYP11B2TRPV3KCNH2 | |
| SCHEMBL20909038 | 0.85 | CYP11B2 (0.45) | PTPN11CYP11B2TRPV3 | |
| SCHEMBL30787853 | 0.83 | PTPN11 (0.63) | PTPN11KCNH2 | |
| SCHEMBL20899399 | 0.83 | PTPN11 (0.63) | PTPN11KCNH2 | |
| SCHEMBL20909039 | 0.78 | PTPN11 (0.47) | PTPN11KCNH2 | |
| SCHEMBL22594980 | 0.77 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL20909056 | 0.77 | PTPN11 (0.68) | PTPN11KCNH2 | |
| SCHEMBL22594735 | 0.77 | PTPN11 (0.62) | PTPN11 | |
| SCHEMBL20909050 | 0.77 | PTPN11 (0.69) | PTPN11KCNH2 | |
| SCHEMBL24151104 | 0.76 | PTPN11 (0.42) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019075265-A1 | PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2019-04-18 | — | — | WO | disclosed |