Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2756735 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTHSD17B10AURKAKIF11 | |
| SCHEMBL618430 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2HTTAURKAALDH1A1HPGD | |
| SCHEMBL21263259 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HTTHSD17B10AURKAKIF11 | |
| SCHEMBL16739826 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HTTHSD17B10AURKAKIF11 | |
| SCHEMBL23664110 | 0.76 | HTT (0.70) | SMN1; SMN2HTTHSD17B10AURKAKIF11 | |
| SCHEMBL15108922 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTHSD17B10AURKAKIF11 | |
| SCHEMBL10141176 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTHSD17B10AURKAKIF11 | |
| SCHEMBL10146396 | 0.74 | AURKA (0.58) | SMN1; SMN2HTTHSD17B10AURKAHPGD | |
| SCHEMBL21604724 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTAURKAALDH1A1HPGD | |
| SCHEMBL7214669 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019074824-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-04-18 | — | — | WO | disclosed |