Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KARS1 | Q15046 | 8/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20913338 | 0.88 | KARS1 (0.55) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL20913337 | 0.88 | SYK (0.49) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL20913328 | 0.88 | MEN1 (0.47) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL1705870 | 0.88 | NPC1 (0.47) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL1702364 | 0.86 | MAPK8 (0.52) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL20913329 | 0.86 | RIOK2 (0.51) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL27097211 | 0.83 | KARS1 (0.52) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL20913317 | 0.82 | MAPT (0.48) | KARS1KDRABL1MAPK8CLK2 | |
| SCHEMBL2912518 | 0.80 | KDR (0.57) | KARS1KDRMAP4K4ABL1LCK | |
| SCHEMBL30471870 | 0.77 | CYP1A2 (0.61) | CYP1A2NCK1BACE1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440546-B1 | COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA | ABIVAX (FR) | 2022-12-28 | — | — | EP | claimed |
| EP-2440547-B1 | New chemical molecules that inhibit the splicing mechanism for the treatment of diseases resulting from splicing defects | ABIVAX (FR) | 2022-11-30 | — | — | EP | claimed |
| EP-2440545-B1 | COMPOUNDS USEFUL FOR TREATING CANCER | ABIVAX (FR) | 2019-04-24 | — | — | EP | claimed |