⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252846 | 0.78 | — | — | |
| SCHEMBL21641901 | 0.77 | TSHR (0.32) | — | |
| SCHEMBL21455383 | 0.75 | ADORA2B (0.32) | — | |
| SCHEMBL826905 | 0.74 | TSHR (0.46) | — | |
| SCHEMBL321296 | 0.74 | TSHR (0.33) | — | |
| SCHEMBL19636496 | 0.72 | HTT (0.31) | — | |
| SCHEMBL4306399 | 0.72 | TSHR (0.43) | — | |
| Ammonia Solution, Strong SCHEMBL28258319 | 0.72 | TSHR (0.43) | — | |
| SCHEMBL10339720 | 0.71 | — | — | |
| SCHEMBL25019679 | 0.70 | TSHR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3697789-A1 | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS | Incyte Corporation (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2019079469-A1 | CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2019-04-25 | — | — | WO | disclosed |