SCHEMBL20922229

SCHEMBL20922229

c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc4c(c3)c3ccccc3n4-c3ccc4sc5c(-c6nc(-c7ccccc7)nc(-c7ccccc7)n6)cccc5c4c3)n2)cc1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.36
RAC2 P15153 1/20 0.33
RAC3 P60763 1/20 0.33
CDC42 P60953 1/20 0.33
RAC1 P63000 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
LIMK1 P53667 1/20 0.32
PTGER4 P35408 1/20 0.31
NPY5R Q15761 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17232214 0.97 LIMK1 (0.35) ALOX5RAC2RAC3CDC42RAC1
SCHEMBL18562286 0.96 KDM4E (0.36) ALOX5RAC2RAC3CDC42RAC1
SCHEMBL22023764 0.96 KDM4E (0.36) ALOX5RAC2RAC3CDC42RAC1
SCHEMBL18562284 0.95 ALOX5 (0.38) ALOX5RAC2RAC3CDC42RAC1
SCHEMBL25714305 0.95 ALOX5 (0.41) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL25928497 0.95 ALOX5 (0.36) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL22329225 0.95 ALOX5 (0.38) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL25928708 0.95 ALOX5 (0.38) ALOX5RAC2RAC3CDC42RAC1
SCHEMBL17231991 0.95 ALOX5 (0.36) ALOX5RAC2RAC3CDC42RAC1
SCHEMBL20922058 0.94 ALOX5 (0.38) ALOX5RAC2RAC3CDC42RAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3533794-B1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2022-02-23 EP disclosed
US-10985330-B2 Materials for electronic devices MERCK PATENT GMBH (DE) 2021-04-20 US disclosed
EP-3533794-A2 MATERIALS FOR ELECTRONIC DEVICES Merck Patent GmbH (DE) 2019-09-04 EP disclosed
US-10355223-B2 Materials for electronic devices MERCK PATENT GMBH (DE) 2019-07-16 US disclosed
EP-3137458-B1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2019-04-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10355223-B2 Materials for electronic devices EPHA3, EPHA6, DDT ALOX5 3691/4885RAC2 361/4885RAC3 246/4885
US-10985330-B2 Materials for electronic devices EPHA3, EPHA6, DDT ALOX5 3691/4885RAC2 361/4885RAC3 246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.