SCHEMBL20923280

SCHEMBL20923280

N#Cc1cc(-c2ccccc2)c(-n2c3cc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)ccc3c3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)cc32)cc1-c1ccncc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 3/20 0.40
S1PR3 Q99500 3/20 0.40
AR P10275 4/20 0.37
CYP19A1 P11511 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
ALOX5AP P20292 2/20 0.36
FEN1 P39748 2/20 0.36
METAP2 P50579 1/20 0.35
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
XDH P47989 2/20 0.34
SCN9A Q15858 3/20 0.34
SCN5A Q14524 1/20 0.34
EPHX2 P34913 1/20 0.34
CYP2C9 P11712 1/20 0.34
PGR P06401 1/20 0.33
EDNRB P24530 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20923278 0.97 S1PR1 (0.38) S1PR1S1PR3ARCYP19A1CYP11B1
SCHEMBL20923604 0.96 S1PR1 (0.42) S1PR1S1PR3ARCYP19A1CYP11B1
SCHEMBL20923603 0.94 S1PR1 (0.40) S1PR1S1PR3ARCYP19A1CYP11B1
SCHEMBL20923172 0.92 S1PR1 (0.38) S1PR1S1PR3ARCYP19A1CYP11B1
SCHEMBL19919764 0.92 ALOX5AP (0.38) S1PR1S1PR3ARALOX5APFEN1
SCHEMBL19919459 0.91 S1PR1 (0.38) S1PR1S1PR3ARCYP19A1CYP11B1
SCHEMBL19909083 0.91 S1PR1 (0.38) S1PR1S1PR3ARCYP19A1CYP11B1
SCHEMBL19919684 0.91 ALOX5AP (0.36) S1PR1S1PR3ARALOX5APFEN1
SCHEMBL20923119 0.91 METAP2 (0.39) CYP19A1CYP11B1CYP11B2METAP2ALDH1A1
SCHEMBL20924136 0.89 S1PR1 (0.42) S1PR1S1PR3ARCYP19A1CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3266772-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-04-24 EP disclosed