Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 3/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20924128 | 0.82 | PRF1 (0.46) | PRF1HDAC6KDM4ETSHRALOX15 | |
| SCHEMBL21341297 | 0.81 | PRF1 (0.43) | PRF1BTKHDAC6ALDH1A1HDAC4 | |
| SCHEMBL16979077 | 0.80 | PRF1 (0.44) | PRF1HDAC6KDM4ETSHRALOX15 | |
| SCHEMBL1500456 | 0.79 | PRF1 (0.46) | PRF1HDAC6KDM4ETSHRALOX15 | |
| SCHEMBL2018210 | 0.79 | PRF1 (0.46) | PRF1HDAC6KDM4ETSHRALOX15 | |
| SCHEMBL14084767 | 0.76 | ALDH1A1 (0.43) | PRF1BTKALDH1A1CA12CA1 | |
| SCHEMBL20924338 | 0.75 | PRF1 (0.61) | PRF1HDAC6KDM4E | |
| SCHEMBL9375738 | 0.75 | KDM4E (0.65) | HDAC6KDM4ETSHRALOX15SIRT1 | |
| SCHEMBL15570900 | 0.74 | PRF1 (0.54) | PRF1KDM4ETSHRALOX15SIRT1 | |
| SCHEMBL15571449 | 0.73 | PRF1 (0.61) | PRF1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888251-B1 | PERFORIN INHIBITING BENZENESULFONAMIDE COMPOUNDS, PREPARATION AND USES THEREOF | PETER MACCALLUM CANCER INST (AU) | 2019-04-24 | — | — | EP | disclosed |