Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 9/20 | 0.67 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24989021 | 0.86 | KDM1A (0.62) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL9798043 | 0.86 | KDM1A (0.52) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL9798050 | 0.86 | KDM1A (0.52) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL9798006 | 0.83 | KDM4E (0.53) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL9797987 | 0.83 | KDM4E (0.53) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL9805343 | 0.82 | KDM1A (0.48) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL9805337 | 0.82 | KDM1A (0.48) | KDM1AEGLN2CYP11B1KDM4EALDH1A1 | |
| SCHEMBL20019516 | 0.82 | KDM1A (0.70) | KDM1ACYP11B1MAOAMAOB | |
| SCHEMBL527912 | 0.80 | KDM1A (1.00) | KDM1AMAOAMAOB | |
| SCHEMBL527570 | 0.80 | KDM1A (1.00) | KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598480-B1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS | ORYZON GENOMICS SA (ES) | 2019-04-24 | — | — | EP | disclosed |