Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895772 | 0.84 | TSHR (0.41) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL18388375 | 0.81 | MAPT (0.41) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL14230109 | 0.78 | CA12 (0.41) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL20697543 | 0.77 | CA2 (0.38) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL18383505 | 0.76 | CA12 (0.39) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL10087947 | 0.74 | CA12 (0.46) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL18558901 | 0.74 | TSHR (0.45) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL14200286 | 0.74 | TSHR (0.33) | CA12CA2CA9TSHRMAPK1 | |
| SCHEMBL6895861 | 0.73 | CA1 (0.44) | CA12CA2CA9TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL28190002 | 0.73 | CA12 (0.44) | CA12CA2CA9TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079649-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION (US) | 2019-04-25 | — | — | WO | disclosed |