Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 15/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.45 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22568711 | 0.91 | IDE (0.52) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20920004 | 0.91 | KIT (0.60) | KITRET | |
| SCHEMBL22568642 | 0.91 | KIT (0.51) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20928384 | 0.90 | KIT (0.50) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL22568780 | 0.89 | KIT (0.47) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20928313 | 0.89 | KIT (0.49) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20927825 | 0.88 | KIT (0.46) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20928153 | 0.88 | KIT (0.46) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20927816 | 0.88 | KIT (0.46) | KITAURKAAURKBINCENPTPX2 | |
| SCHEMBL20928412 | 0.88 | KIT (0.51) | KITAURKAAURKBINCENPTPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079649-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION (US) | 2019-04-25 | — | — | WO | disclosed |