Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.77 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12003129 | 1.00 | ADORA2A (0.77) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 | |
| SCHEMBL4220368 | 1.00 | ADORA2A (0.77) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL1401969 | 0.88 | ADORA2A (0.89) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 | |
| SCHEMBL2089933 | 0.84 | ADORA3 (0.52) | ADORA2AADORA3ADORA1SMN1; SMN2 | |
| SCHEMBL239969 | 0.84 | ADORA3 (0.52) | ADORA2AADORA3ADORA1SMN1; SMN2 | |
| SCHEMBL592233 | 0.82 | ADORA2A (0.54) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 | |
| SCHEMBL592232 | 0.81 | ADORA2A (0.55) | ADORA2AADORA3ADORA2BADORA1ALDH1A1 | |
| SCHEMBL1402078 | 0.78 | ADORA2A (0.51) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2088729 | 0.78 | ADORA2A (0.51) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL1401963 | 0.77 | ADORA2A (0.59) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163754-B2 | inflammatory or obstructive airways diseases; in combination with an antiinflammatory, bronchodilatory, antihistamine or anti-tussive; N-[4-(6-Amino-2-phenethylamino-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide | NOVARTIS AG (CH) | 2012-04-24 | — | — | US | disclosed |
| US-20080200483-A1 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists | NOVARTIS AG (CH) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200483-A1 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.