Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640126 | 0.97 | ALDH1A1 (0.55) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| Phosphoric Acid SCHEMBL15110084 | 0.85 | HPGD (0.48) | ALDH1A1TSHRNPC1RAB9ACA12 | |
| Hydrochloric Acid SCHEMBL1876474 | 0.83 | CYP1A2 (0.53) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| Hydrochloric Acid SCHEMBL28417225 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| SCHEMBL39645 | 0.80 | CYP1A2 (0.55) | ALDH1A1TSHRAOC3MGLLNPC1 | |
| Hydrochloric Acid SCHEMBL3895103 | 0.79 | AOC3 (0.56) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| Hydrochloric Acid SCHEMBL10565954 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| Hydrochloric Acid SCHEMBL27833055 | 0.79 | ALDH1A1 (0.48) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| Hydrochloric Acid SCHEMBL2115265 | 0.79 | AOC3 (0.56) | ALDH1A1TSHRAOC3MGLLGRIN2D | |
| Pyrophosphoric Acid SCHEMBL15110085 | 0.79 | TSHR (0.46) | ALDH1A1TSHRNPC1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247825-A1 | CARBON MONOXIDE AS A TREATMENT FOR NEURODEGENERATIVE DISEASE | THE GENERAL HOSPITAL CORPORATION (US) | 2020-12-10 | — | — | WO | disclosed |
| US-8106388-B2 | Quantum dot solar cell with rigid bridge molecule | HONEYWELL INTERNATIONAL INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-8089063-B2 | Quantum dot solar cell with electron rich anchor group | HONEYWELL INTERNATIONAL INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8067763-B2 | Quantum dot solar cell with conjugated bridge molecule | HONEYWELL INTERNATIONAL INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090159131-A1 | QUANTUM DOT SOLAR CELL WITH RIGID BRIDGE MOLECULE | HONEYWELL INTERNATIONAL INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090159120-A1 | QUANTUM DOT SOLAR CELL WITH CONJUGATED BRIDGE MOLECULE | HONEYWELL INTERNATIONAL INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090159999-A1 | QUANTUM DOT SOLAR CELL WITH ELECTRON RICH ANCHOR GROUP | HONEYWELL INTERNATIONAL INC. (US) | 2009-06-25 | — | — | US | disclosed |
| EP-1807386-A4 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2008-09-17 | — | — | EP | disclosed |
| US-7407989-B2 | Compounds useful for modulating abnormal cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2008-08-05 | — | — | US | disclosed |
| US-20070185123-A1 | Novel compounds useful for modulating abnormal cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-09 | — | — | US | disclosed |
| EP-1807386-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-07-18 | — | — | EP | disclosed |
| US-7202383-B2 | Compounds useful for modulating abnormal cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-04-10 | — | — | US | disclosed |
| WO-2006029516-A1 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058554-A1 | Novel compounds useful for modulating abnormal cell proliferation | THE HOSPITAL FOR SICK CHILDREN | 2006-03-16 | — | — | US | disclosed |
| EP-0342211-A1 | TREATMENT OF ARTERIOSCLEROSIS BY ADMINISTRATION OF L-TRYPTOPHAN OR L-5-HYDROXYTRYPTOPHAN. | UNIV FLORIDA (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989002737-A1 | TREATMENT OF HYPERTENSION BY CHRONIC ADMINISTRATION OF L-TRYPTOPHAN OR L-5-HYDROXYTRYPTOPHAN | UNIVERSITY OF FLORIDA (US) | 1989-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185123-A1 | Novel compounds useful for modulating abnormal cell proliferation | CCNA1, CCNE1, CCND3 | GRIN2A 4371/4885ALDH1A1 446/4885TSHR 1866/4885 |
| US-20060058554-A1 | Novel compounds useful for modulating abnormal cell proliferation | CCNA1, CCNE1, CCND3 | GRIN2A 4415/4885ALDH1A1 447/4885TSHR 1928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.