SCHEMBL20937828

SCHEMBL20937828

Cc1ccc2c3ccc(C)cc3n(-c3ccc(-c4cccnc4)cc3-c3nc(-c4ccccc4)nc(-c4ccccc4)n3)c2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 4/20 0.41
PDE5A O76074 2/20 0.41
CYP3A4 P08684 4/20 0.40
CYP11B1 P15538 3/20 0.40
CYP17A1 P05093 2/20 0.40
CYP19A1 P11511 2/20 0.40
ADORA3 P0DMS8 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
MAPT P10636 3/20 0.39
MAPK1 P28482 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
HTT P42858 1/20 0.39
TP53 P04637 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
ALDH1A1 P00352 3/20 0.38
CYP1A2 P05177 3/20 0.38
CYP2D6 P10635 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24797950 0.97 CYP11B2 (0.39) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1
SCHEMBL20937728 0.95 CYP11B2 (0.42) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1
SCHEMBL20937851 0.94 CYP11B2 (0.41) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1
SCHEMBL20937841 0.92 MAPT (0.41) CYP11B2CYP3A4CYP11B1CYP17A1CYP19A1
SCHEMBL20937727 0.92 CYP11B2 (0.41) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1
SCHEMBL20937820 0.91 PDE5A (0.43) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1
SCHEMBL20937368 0.91 MAPT (0.41) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1
SCHEMBL20937578 0.91 CYP11B2 (0.43) CYP11B2CYP3A4CYP11B1CYP17A1CYP19A1
SCHEMBL20937409 0.91 CYP11B2 (0.43) CYP11B2CYP3A4CYP11B1CYP17A1CYP19A1
SCHEMBL20937848 0.91 CYP3A4 (0.41) CYP11B2PDE5ACYP3A4CYP11B1CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3697865-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO LTD (KR) 2022-12-28 EP disclosed
WO-2019076844-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-04-25 WO disclosed