Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.84 |
| ▸ | BRD2 | P25440 | 2/20 | 0.72 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.72 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CCL2 | P13500 | 1/20 | 0.72 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.72 |
| ▸ | TACR1 | P25103 | 1/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.72 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.72 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.72 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15985143 | 0.91 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL14756742 | 0.91 | BRD4 (0.84) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL22053933 | 0.90 | BRD4 (0.83) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL22053929 | 0.90 | BRD4 (0.83) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL28723583 | 0.87 | BRD4 (0.76) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL1906250 | 0.87 | BRD4 (0.81) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL18908638 | 0.86 | BRD4 (0.74) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL18908655 | 0.85 | BRD4 (0.73) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL29516834 | 0.85 | BRD4 (0.73) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL18908663 | 0.85 | BRD4 (0.73) | BRD4BRD2BRD3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10702518-B2 | TAF1 inhibitors for the therapy of cancer | CeMM—FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH (AT) | 2020-07-07 | — | — | US | disclosed |
| US-20190262355-A1 | COMBINATION OF A BRD4 INHIBITOR AND AN ANTIFOLATE FOR THE THERAPY OF CANCER | CEMM-FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2019-08-29 | — | — | US | disclosed |
| US-20190117641-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117641-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | TAF1, TAF1L, TAF5 | BRD4 27/4885BRD2 35/4885BRD3 28/4885 |
| US-10702518-B2 | TAF1 inhibitors for the therapy of cancer | TAF1, TAF1L, TAF5 | BRD4 27/4885BRD2 35/4885BRD3 28/4885 |
| US-20190262355-A1 | COMBINATION OF A BRD4 INHIBITOR AND AN ANTIFOLATE FOR THE THERAPY OF CANCER | BRD4, MTHFD1, BICRA | BRD4 1/4885BRD2 12/4885BRD3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.