MTHFD1

C-1-tetrahydrofolate synthase, cytoplasmic · P11586 · MTHFD1 on Sugi Atlas →

2,600 patent compounds predicted against MTHFD1, 2,028 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5370174	0.46	4/20
Ketotrexate (SCHEMBL1228871)	0.80	3/20
SCHEMBL188064	0.70	3/20
SCHEMBL258924	0.70	3/20
SCHEMBL3181068	0.70	3/20
Levomefolic Acid (SCHEMBL79586)	0.68	3/20
Levomefolic Acid (SCHEMBL7953180)	0.68	3/20
Levomefolic Acid (SCHEMBL3442396)	0.67	3/20
SCHEMBL10928467	0.66	3/20
SCHEMBL2166341	0.63	3/20
SCHEMBL1537882	0.59	3/20
SCHEMBL9413322	0.59	3/20
Arfolitixorin (SCHEMBL4109116)	0.59	3/20
Leucovorin (SCHEMBL8349)	0.58	3/20
Leucovorin (SCHEMBL8350)	0.58	3/20
Levoleucovorin (SCHEMBL571901)	0.58	3/20
Leucovorin (SCHEMBL571902)	0.58	3/20
Leucovorin (SCHEMBL4708750)	0.58	3/20
Leucovorin (SCHEMBL5132046)	0.58	3/20
Dihydrofolic Acid (SCHEMBL8281)	0.57	3/20

Clinical trials — most relevant to MTHFD1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM	PHASE3	COMPLETED
Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine	PHASE2/PHASE3	UNKNOWN
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis	PHASE3	COMPLETED
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	PHASE2	COMPLETED
A Study to Assess CH1504 in Patients With Active Rheumatoid Arthritis	PHASE2	COMPLETED
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer	PHASE2	UNKNOWN
Pemetrexed, Carboplatin, and Bevacizumab as First-Line Therapy in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer	PHASE2	COMPLETED
Study Using FolateScan to Identify Subjects With Folate Receptor-Positive Metastatic Renal Cell Carcinoma	PHASE2	COMPLETED
Pemetrexed Disodium With or Without Sorafenib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer	PHASE2	COMPLETED
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma	PHASE2	UNKNOWN
Folate Rechallenge	PHASE2	COMPLETED
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study	PHASE2	UNKNOWN
Ivonescimab Alone And With Carboplatin/Pemetrexed For NSCLC	PHASE2	NOT_YET_RECRUITING
Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE1	COMPLETED
C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine Effectiveness in Metastatic Colon Cancer	nan	UNKNOWN
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524	nan	COMPLETED
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial	nan	NOT_YET_RECRUITING
Where is the Initial Site of Biotransformation of Folates in Humans?	nan	COMPLETED
DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization	nan	COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant Women	nan	RECRUITING
PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer	nan	UNKNOWN
Predicting Response to Capecitabine in Women With Metastatic Breast Cancer	nan	COMPLETED
Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study	nan	COMPLETED
Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate	nan	COMPLETED
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Assessing Colonic Folate Absorption & Metabolism	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a MTHFD1 binder may also engage these)

Protein	Name	Similarity
Q5R8P0	—	1.000	Q5R8P0 →
O96553	—	0.999	O96553 →
Q922D8	—	0.999	Q922D8 →
A8FEC9	—	0.998	A8FEC9 →
B9IYP4	—	0.998	B9IYP4 →
P27653	—	0.998	P27653 →
A6LAR6	—	0.997	A6LAR6 →
Q2YTF6	—	0.997	Q2YTF6 →
Q6G8J5	—	0.997	Q6G8J5 →
P0DF93	—	0.997	P0DF93 →
Q81RE1	—	0.997	Q81RE1 →
Q63C61	—	0.997	Q63C61 →
A6U2J8	—	0.997	A6U2J8 →
Q5M4U2	—	0.997	Q5M4U2 →
Q8E5E3	—	0.997	Q8E5E3 →
P07245	—	0.997	P07245 →
Q8NZ49	—	0.997	Q8NZ49 →
Q8WZJ7	—	0.996	Q8WZJ7 →
A6QHR5	—	0.996	A6QHR5 →
Q81E87	—	0.996	Q81E87 →
Q2K5P2	—	0.996	Q2K5P2 →
Q5M083	—	0.996	Q5M083 →
Q04FS6	—	0.996	Q04FS6 →
Q71YD9	—	0.996	Q71YD9 →
A6UBV0	—	0.996	A6UBV0 →
B8DDM6	—	0.996	B8DDM6 →
Q97QI2	—	0.996	Q97QI2 →
B3PV59	—	0.996	B3PV59 →
A3CL27	—	0.996	A3CL27 →
Q8NW37	—	0.996	Q8NW37 →