⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10562763 | 0.73 | — | — | |
| SCHEMBL337169 | 0.73 | — | — | |
| SCHEMBL19657152 | 0.73 | — | — | |
| SCHEMBL28858723 | 0.71 | KDM4E (0.39) | — | |
| SCHEMBL12680133 | 0.69 | KDM4E (0.32) | — | |
| SCHEMBL5176644 | 0.69 | HTT (0.43) | — | |
| SCHEMBL12120877 | 0.69 | HTT (0.43) | — | |
| SCHEMBL2639006 | 0.69 | KDM4E (0.37) | — | |
| SCHEMBL15255473 | 0.69 | HTT (0.43) | — | |
| Fumaric Acid SCHEMBL9689356 | 0.65 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4751557-B2 | — | — | 2011-08-17 | — | — | JP | claimed |
| EP-1278717-B1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL|-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LAB LTD (IN) | 2007-06-06 | — | — | EP | claimed |
| EP-1278717-A4 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LAB LTD (IN) | 2005-06-08 | — | — | EP | claimed |
| US-20040267019-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO -2-[2,4-DIBROMO-3-(DIFLUROMETHOXY) BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | TOYAMA CHEMICAL COMPANY, LIMITED (JP) | 2004-12-30 | — | — | US | claimed |
| US-6835848-B1 | Reacting 2,4-dibromo-3-(difluoromethoxy)benzoic acid with a halogenating agent to get a corresponding acid chloride, then reacting with a 3-(dialkylamino)acrylic acid alkyl ester and then cyclopropylamine | RANBAXY LABORATORIES LIMITED (IN) | 2004-12-28 | — | — | US | claimed |
| EP-1278717-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | Ranbaxy Laboratories Limited (IN) | 2003-01-29 | — | — | EP | claimed |
| WO-2001066512-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2-[2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LABORATORIES LIMITED (IN) | 2001-09-13 | — | — | WO | claimed |
| US-8163769-B2 | 1,8-naphthyridine derivatives | ABBOTT LABORATORIES (US) | 2012-04-24 | — | — | US | disclosed |
| EP-1636190-A1 | STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND | Japan Tobacco, Inc. (JP) | 2006-03-22 | — | — | EP | disclosed |
| EP-1631570-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | Abbott Laboratories (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2005113508-A1 | STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND | JAPAN TOBACCO INC. (JP) | 2005-12-01 | — | — | WO | disclosed |
| US-6818654-B2 | 1,2,3,4-TETRAHYDROQUINOLINE- OR 1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE DERIVATIVES; TREATING INFECTIONS IN FISH OR MAMMALS | ABBOTT LABORATORIES | 2004-11-16 | — | — | US | disclosed |
| WO-2004083207-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ABBOTT LABORATORIES (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040072817-A1 | Antibacterial compounds | ABBVIE INC. | 2004-04-15 | — | — | US | disclosed |
| US-20030232818-A1 | Antibacterial compounds | ABBVIE INC. | 2003-12-18 | — | — | US | disclosed |