Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 14/20 | 0.49 |
| ▸ | RXRA | P19793 | 7/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20944805 | 0.94 | TDP1 (0.49) | TDP1RXRAPTPRC | |
| SCHEMBL20944813 | 0.86 | RXRA (0.63) | TDP1RXRAPTPRC | |
| SCHEMBL16312476 | 0.83 | TDP1 (0.60) | TDP1RXRA | |
| SCHEMBL20963320 | 0.81 | IDO1 (0.48) | TDP1RXRAPTPRCMAPTMAPK1 | |
| SCHEMBL20944792 | 0.77 | RXRA (0.48) | TDP1RXRAMAPTKMT2A | |
| SCHEMBL12877803 | 0.76 | PTPRC (0.66) | TDP1RXRAPTPRCMAPK1 | |
| SCHEMBL20944793 | 0.76 | RXRA (0.45) | TDP1RXRA | |
| SCHEMBL28427738 | 0.75 | CCNB2 (0.52) | TDP1RXRAPTPRCMAPTKMT2A | |
| SCHEMBL4449715 | 0.75 | TDP1 (0.44) | TDP1RXRAPTPRCNPC1MAPK1 | |
| SCHEMBL20944797 | 0.74 | TDP1 (0.46) | TDP1RXRANPC1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3480187-B1 | METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES | UNIV NAT TAIWAN NORMAL (TW) | 2023-10-04 | — | — | EP | disclosed |
| EP-3480187-B1 | METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES | UNIV NAT TAIWAN NORMAL (TW) | 2023-10-04 | — | — | EP | disclosed |
| US-10336704-B2 | Method for preparing indenoisoquinoline derivatives | NATIONAL TAIWAN NORMAL UNIVERSITY (TW) | 2019-07-02 | — | — | US | disclosed |
| US-10336704-B2 | Method for preparing indenoisoquinoline derivatives | NATIONAL TAIWAN NORMAL UNIVERSITY (TW) | 2019-07-02 | — | — | US | disclosed |
| EP-3480187-A1 | METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES | National Taiwan Normal University (TW) | 2019-05-08 | — | — | EP | disclosed |
| EP-3480187-A1 | METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES | National Taiwan Normal University (TW) | 2019-05-08 | — | — | EP | disclosed |
| US-20190127330-A1 | Method for Preparing Indenoisoquinoline Derivatives | NATIONAL TAIWAN NORMAL UNIVERSITY (TW) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336704-B2 | Method for preparing indenoisoquinoline derivatives | CYP1A2, RECQL, RDX | TDP1 3167/4885RXRA 1260/4885PTPRC 4361/4885 |
| US-20190127330-A1 | Method for Preparing Indenoisoquinoline Derivatives | CYP1A2, RECQL, RDX | TDP1 3167/4885RXRA 1260/4885PTPRC 4361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.