Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16107670 | 0.93 | NAMPT (0.55) | NAMPTIDO1CYP2C9KDM4E | |
| SCHEMBL16107985 | 0.89 | NAMPT (0.73) | NAMPTCYP2C9 | |
| SCHEMBL24859190 | 0.87 | NAMPT (0.63) | NAMPTHDAC2CYP2C9 | |
| SCHEMBL27942036 | 0.80 | SRC (0.46) | NAMPTHDAC2IDO1CYP2C9KDM4E | |
| SCHEMBL15531862 | 0.78 | NAMPT (0.58) | NAMPTCYP2C9 | |
| SCHEMBL16107633 | 0.77 | NAMPT (0.68) | NAMPTCYP2C9 | |
| SCHEMBL12467914 | 0.76 | NAMPT (1.00) | NAMPTCYP2C9 | |
| SCHEMBL16107643 | 0.75 | SRC (0.57) | NAMPTIDO1CYP2C9KDM4E | |
| SCHEMBL12467958 | 0.75 | NAMPT (0.69) | NAMPTCYP2C9 | |
| SCHEMBL18750643 | 0.75 | HDAC2 (0.67) | HDAC2IDO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10272072-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10272072-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | NAMPT 1/4885HDAC2 324/4885IDO1 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.