Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 18/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21524086 | 0.86 | NAMPT (0.67) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL21524157 | 0.86 | NAMPT (0.79) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL22419482 | 0.85 | NAMPT (0.74) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL30167830 | 0.85 | NAMPT (1.00) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL161050 | 0.85 | NAMPT (1.00) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL22419450 | 0.85 | NAMPT (0.70) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL21524191 | 0.84 | NAMPT (0.76) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL20953233 | 0.84 | NAMPT (0.69) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL22419577 | 0.84 | NAMPT (0.82) | NAMPTHDAC3HDAC1HDAC2CYP2C9 | |
| SCHEMBL22419484 | 0.83 | NAMPT (0.78) | NAMPTHDAC3HDAC1HDAC2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10456382-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2019-10-29 | — | — | US | disclosed |
| US-10272072-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10272072-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | NAMPT 1/4885HDAC3 89/4885HDAC1 175/4885 |
| US-10456382-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | NAMPT 1/4885HDAC3 89/4885HDAC1 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.