Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoniazid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.95 |
| ▸ | MPO | P05164 | 2/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.95 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.95 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.95 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoniazid SCHEMBL2390873 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL12264078 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL16642160 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL228 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL16642161 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL12264083 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL12264081 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL2072618 | 0.98 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL7502798 | 0.95 | KDM4E (0.95) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL2993076 | 0.95 | KDM4E (0.95) | KDM4ECYP3A4MPOCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109768012-B | Chip comprising on-board non-volatile memory containing phase change material | 意法半导体(格勒诺布尔2)公司 | 2023-12-08 | — | — | CN | disclosed |
| US-20230263082-A1 | CHIP CONTAINING AN ONBOARD NON-VOLATILE MEMORY COMPRISING A PHASE-CHANGE MATERIAL | STMICROELECTRONICS (CROLLES 2) SAS (FR) | 2023-08-17 | — | — | US | disclosed |
| US-11653582-B2 | Chip containing an onboard non-volatile memory comprising a phase-change material | STMICROELECTRONICS (CROLLES 2) SAS (FR) | 2023-05-16 | — | — | US | disclosed |
| US-20190140176-A1 | CHIP CONTAINING AN ONBOARD NON-VOLATILE MEMORY COMPRISING A PHASE-CHANGE MATERIAL | STMICROELECTRONICS (CROLLES 2) SAS (FR) | 2019-05-09 | — | — | US | disclosed |