Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoniazid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | MPO | P05164 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | KDM5A | P29375 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoniazid SCHEMBL16642160 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL12264078 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL2390873 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL2072618 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL16642161 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL12264083 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL12264081 | 1.00 | KDM4E (1.00) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL7502798 | 0.98 | KDM4E (0.95) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL20958129 | 0.98 | KDM4E (0.95) | KDM4ECYP3A4MPOCYP1A2CYP2D6 | |
| Isoniazid SCHEMBL2993076 | 0.98 | KDM4E (0.95) | KDM4ECYP3A4MPOCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 167784 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746711-A1 | COMPOSITIONS COMPRISING A MIXTURE OF LIPO-CHITOOLIGOSACCHARIDE(S) AND PLANT BIOSTIMULANT(S), AND USES THEREOF FOR INCREASING PLANT GROWTH AND CROP YIELDS | 11584022 Canada Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| CN-122080895-A | Polyglycolic acid composition and preparation method thereof, biodegradable polyester material and application thereof, and PGA temporary plugging ball and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122084594-A | Quick phenotype drug sensitivity detection method for mycobacterium tuberculosis infection sample | — | 2026-05-26 | — | — | CN | claimed |
| CN-117045657-B | Pharmaceutical composition and application thereof | Guangzhou Jiayue Pharmaceutical Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026104587-A1 | CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS | ADJUTEC PHARMA AS (NO) | 2026-05-21 | — | — | WO | claimed |
| US-20260137766-A1 | LIPOSOME FORMULATIONS FOR TREATMENT OF ACTIVE TUBERCULOSIS | ARCHIVEL FARMA S L (ES) | 2026-05-21 | — | — | US | claimed |
| EP-4743586-A1 | DETECTION METHOD FOR MYCOBACTERIA | The Royal Veterinary College (GB) | 2026-05-20 | — | — | EP | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| CN-122031714-A | Surface-specific ligand-guided nano mesoporous drug carrier and preparation method thereof | 广州墨羲科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031715-A | Nanoscale delivery system based on specific bioselectivity enhancement and preparation method and application thereof | 广州墨羲科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-3966656-A | FIBER AND FILM FORMING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-06-29 | — | — | US | claimed |
| US-3963691-A | POLYPEPTIDES, PEPTIZATION | MERCK & CO., INC. (US) | 1976-06-15 | — | — | US | claimed |
| US-3959080-A | Carrier matrix for the fixation of biochemically effective substances and process for the preparation thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-05-25 | — | — | US | claimed |
| US-3957735-A | FIBER-FORMING POLYHYDRAZIDES | MONSANTO COMPANY (US) | 1976-05-18 | — | — | US | claimed |
| US-3954607-A | Permselective membranes of diacyl hydrazide-containing aromatic polymers having selected metals complexed therewith | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-05-04 | — | — | US | claimed |
| US-3950278-A | AMORPHOUS PROPYLENE POLYMER, MIXING | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-04-13 | — | — | US | claimed |
| US-3948863-A | Solid, water-insoluble polypeptides having ionizable side chains | AJINOMOTO CO., INC. (JA) | 1976-04-06 | — | — | US | claimed |
| US-3947352-A | Polysaccharide matrices for use as adsorbents in affinity chromatography techniques | CUATRECASAS PEDRO | 1976-03-30 | — | — | US | claimed |
| US-3945991-A | Heterocyclic azo compounds containing a quaternated hydrazide group | CIBA-GEIGY AG (CH) | 1976-03-23 | — | — | US | claimed |
| US-3944522-A | P-PHENYLENE TEREPHTHALAMIDE, TEREPHTHAL HYDRAZIDE, AND P-BENZAMIDE | TORAY INDUSTRIES, INC. (JA) | 1976-03-16 | — | — | US | claimed |