Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 13/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12502227 | 0.93 | TOP2A (0.45) | TOP2ATOP2BNOTUMRORCKDM4E | |
| SCHEMBL1290124 | 0.93 | TOP2A (0.37) | TOP2ATOP2BNOTUMRORCKDM4E | |
| SCHEMBL1290023 | 0.92 | TOP2A (0.36) | TOP2ATOP2BNOTUMRORC | |
| SCHEMBL20083157 | 0.91 | SCN9A (0.34) | TOP2ATOP2B | |
| SCHEMBL1290217 | 0.90 | BRD4 (0.36) | TOP2ATOP2BNOTUMRORC | |
| SCHEMBL20083158 | 0.90 | TOP2A (0.35) | TOP2ATOP2BNOTUMRORC | |
| SCHEMBL20083284 | 0.90 | TOP2A (0.35) | TOP2ATOP2BNOTUMRORCSMN1; SMN2 | |
| SCHEMBL12502348 | 0.90 | TOP2A (0.46) | TOP2ATOP2BNOTUMRORCKDM4C | |
| SCHEMBL1290199 | 0.89 | RORC (0.35) | TOP2ATOP2BNOTUMRORC | |
| SCHEMBL1289943 | 0.88 | TOP2A (0.34) | TOP2ATOP2BNOTUMRORCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3476844-A1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | Emergent Product Development Gaithersburg Inc. (US) | 2019-05-01 | — | — | EP | disclosed |