Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24198636 | 1.00 | MCL1 (0.43) | MCL1FAAHKDM4EMAPK1HIF1A | |
| SCHEMBL3265866 | 0.97 | MCL1 (0.44) | MCL1FAAHKDM4EMAPK1HIF1A | |
| SCHEMBL20960533 | 0.82 | KMT2A (0.50) | MCL1FAAHMMP1MMP2MMP3 | |
| SCHEMBL12661037 | 0.82 | KDM4E (0.40) | KDM4EMAPK1HIF1ATSHRPAOX | |
| SCHEMBL16802010 | 0.82 | KMT2A (0.50) | MCL1FAAHMMP1MMP2MMP3 | |
| SCHEMBL21153346 | 0.80 | MCL1 (0.48) | MCL1FAAHMMP1MMP2MMP3 | |
| SCHEMBL468870 | 0.80 | CTH (0.44) | FAAHKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL19509410 | 0.80 | KDM4E (0.39) | MCL1KDM4EMAPK1HIF1ATSHR | |
| SCHEMBL468799 | 0.80 | CTH (0.44) | FAAHKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL13660541 | 0.80 | MCL1 (0.43) | MCL1FAAHMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961435-B1 | CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS | IMMUNOGEN INC (US) | 2019-05-01 | — | — | EP | disclosed |