Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 9/20 | 1.00 |
| ▸ | PARP1 | P09874 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM4B | O94953 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30700362 | 0.98 | PDPK1 (0.96) | PDPK1PARP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL913347 | 0.76 | PDPK1 (0.61) | PDPK1PARP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3552668 | 0.73 | PDPK1 (0.58) | PDPK1PARP1AXLMKNK1MKNK2 | |
| SCHEMBL1991594 | 0.70 | — | — | |
| SCHEMBL6266906 | 0.70 | SMN1; SMN2 (0.59) | PDPK1PARP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10915904 | 0.68 | PDPK1 (0.52) | PDPK1PARP1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL2576996 | 0.68 | PDPK1 (0.52) | PDPK1PARP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1457910 | 0.68 | PDPK1 (0.52) | PDPK1PARP1MEN1KMT2AALDH1A1 | |
| SCHEMBL3417708 | 0.68 | PDPK1 (0.52) | PDPK1PARP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL652836 | 0.68 | PARP1 (0.52) | PDPK1PARP1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 496 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11730742-B2 | Pharmaceutical use of thiophene [3,2-d] pyrimidine-4-ketone compound | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-08-22 | — | — | US | claimed |
| CN-114524826-A | Preparation process of 7-bromo-4-chlorothiophene [3,2-d ] pyrimidine | 郑州猫眼农业科技有限公司 | 2022-05-24 | — | — | CN | claimed |
| US-20210015824-A1 | NOVEL PHARMACEUTICAL USE OF THIOPHENE [3,2-D] PYRIMIDINE-4-KETONE COMPOUND | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-01-21 | — | — | US | claimed |
| EP-3763716-A1 | NOVEL PHARMACEUTICAL USE OF THIOPHENE [3, 2-D] PYRIMIDINE-4-KETONE COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-01-13 | — | — | EP | claimed |
| EP-2786998-B1 | THIENYL [3, 2-D]PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2018-07-25 | — | — | EP | claimed |
| US-9045491-B2 | Thienyl [3,2-D] pyrimidin-4-one compounds, preparation method, pharmaceutical compositions and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2015-06-02 | — | — | US | claimed |
| US-20140323466-A1 | THIENYL [3,2-D] PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2014-10-30 | — | — | US | claimed |
| EP-2786998-A1 | THIENYL [3, 2-D]PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2014-10-08 | — | — | EP | claimed |
| CN-1894234-A | Dipeptidyl peptidase inhibitors | SYRRX INC (JP) | 2007-01-10 | — | — | CN | claimed |
| EP-1608317-A4 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2006-12-27 | — | — | EP | claimed |
| EP-0900799-B1 | Novel atropisomers of 2,3-disubstituted-(5,6)-heteroarylfused-pyrimidin-4-ones | PFIZER PROD INC (US) | 2005-06-08 | — | — | EP | claimed |
| CN-1596247-A | Lactam derivatives as antagonists of the human 11CBY receptor | SMITHKLINE BEECHAM PLC (GB) | 2005-03-16 | — | — | CN | claimed |
| US-20050004117-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2005-01-06 | — | — | US | claimed |
| US-20040259870-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-23 | — | — | US | claimed |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | claimed |
| WO-2004087053-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX, INC. (US) | 2004-10-14 | — | — | WO | claimed |
| US-6323208-B1 | COMPOUNDS TO TREAT NEURODEGENERATIVE, PSYCHOTROPIC DRUG AND ALCOHOL INDUCED CENTRAL AND INDUCED CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS. | PFIZER INC | 2001-11-27 | — | — | US | claimed |
| EP-0992240-A1 | THERAPEUTIC AGENT FOR ERECTION FAILURE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-12 | — | — | EP | claimed |
| EP-0900799-A1 | Novel atropisomers of 2,3-disubstituted-(5,6)-heteroarylfused-pyrimidin-4-ones | Pfizer Products Inc. (US) | 1999-03-10 | — | — | EP | claimed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004117-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP4, DPP3 | PDPK1 3110/4885PARP1 3791/4885SMN1; SMN2 3765/4885 |
| US-11730742-B2 | Pharmaceutical use of thiophene [3,2-d] pyrimidine-4-ketone compound | DPP4, DPP7, DPP3 | PDPK1 132/4885PARP1 2650/4885SMN1; SMN2 3176/4885 |
| US-20140323466-A1 | THIENYL [3,2-D] PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | DPP4, DPP7, DPP3 | PDPK1 147/4885PARP1 2350/4885SMN1; SMN2 3392/4885 |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP4, DPP3 | PDPK1 2094/4885PARP1 1840/4885SMN1; SMN2 4426/4885 |
| US-20040259870-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP4, DPP3 | PDPK1 2001/4885PARP1 1828/4885SMN1; SMN2 4500/4885 |
| US-20210015824-A1 | NOVEL PHARMACEUTICAL USE OF THIOPHENE [3,2-D] PYRIMIDINE-4-KETONE COMPOUND | DPP4, DPP7, DPP3 | PDPK1 132/4885PARP1 2683/4885SMN1; SMN2 3239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.