Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223087 | 1.00 | PSMB8 (0.47) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL10222792 | 0.85 | SCN3A (0.57) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL24731039 | 0.84 | SCN3A (0.55) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL13191471 | 0.82 | ULK1 (0.48) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL10223109 | 0.82 | ULK1 (0.48) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL28638185 | 0.82 | PSMB8 (0.44) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL18849682 | 0.82 | PSMB8 (0.44) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL18849736 | 0.82 | PSMB8 (0.44) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL28638344 | 0.82 | PSMB8 (0.44) | PSMB8SCN3ASCN9AULK1DHODH | |
| SCHEMBL12403439 | 0.81 | SCN3A (0.47) | PSMB8SCN3ASCN9AULK1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127365-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127365-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | PSMB8 985/4885SCN3A 4477/4885SCN9A 4479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.