Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR2 | P37173 | 2/20 | 0.49 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 6/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990583 | 0.81 | TGFBR2 (0.50) | TGFBR2ACVR2ATGFBR1JAK2PIM1 | |
| SCHEMBL4332309 | 0.78 | PIM1 (0.47) | AXLGSK3BPIM1RETPIM2 | |
| SCHEMBL15891411 | 0.76 | RET (0.53) | PIM1RETPIM2 | |
| SCHEMBL15891337 | 0.76 | PIM1 (0.61) | PIM1RETPIM2IRAK4CDK2 | |
| SCHEMBL18208666 | 0.76 | JAK2 (0.50) | TGFBR2ACVR2ATGFBR1JAK2RET | |
| SCHEMBL23148335 | 0.75 | NTRK1 (0.43) | AXLJAK2MAP4K4NTRK1NTRK2 | |
| SCHEMBL23148336 | 0.75 | NTRK1 (0.43) | AXLJAK2MAP4K4NTRK1NTRK2 | |
| SCHEMBL1440944 | 0.74 | CDK2 (0.39) | AXLPIM1DYRK3NTRK1CDK1 | |
| SCHEMBL1441016 | 0.74 | NTRK1 (0.35) | AXLNTRK1NTRK2FYN | |
| SCHEMBL1442100 | 0.74 | PIM1 (0.36) | AXLPIM1PIM2NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676486-B2 | Macrocyclic RIP2 kinase inhibitors | ONCODESIGN S.A. (FR) | 2020-06-09 | — | — | US | disclosed |
| US-20190127390-A1 | MACROCYCLIC RIP2 KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127390-A1 | MACROCYCLIC RIP2 KINASE INHIBITORS | RIPK2, RIPK1, RIPK3 | TGFBR2 2295/4885ACVR2A 764/4885TGFBR1 3711/4885 |
| US-10676486-B2 | Macrocyclic RIP2 kinase inhibitors | RIPK2, RIPK1, RIPK3 | TGFBR2 2295/4885ACVR2A 764/4885TGFBR1 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.