Sugi Predict

Sugi Predict / Compounds / SCHEMBL20972761

SCHEMBL20972761

SCHEMBL20972761

CC(C)CC(=O)/C=C/C=C/c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC3 O15379 2/20 0.53
▸ HDAC4 P56524 2/20 0.53
▸ HDAC1 Q13547 2/20 0.53
▸ HDAC7 Q8WUI4 2/20 0.53
▸ HDAC2 Q92769 2/20 0.53
▸ HDAC10 Q969S8 2/20 0.53
▸ HDAC11 Q96DB2 2/20 0.53
▸ HDAC8 Q9BY41 2/20 0.53
▸ HDAC6 Q9UBN7 2/20 0.53
▸ HDAC9 Q9UKV0 2/20 0.53
▸ HDAC5 Q9UQL6 2/20 0.53
▸ ALDH1A1 P00352 6/20 0.49
▸ SMN1; SMN2 Q16637 3/20 0.49
▸ MAOB P27338 5/20 0.49
▸ RAB9A P51151 2/20 0.46
▸ HPGD P15428 1/20 0.46
▸ TDP1 Q9NUW8 2/20 0.46
▸ GLA P06280 1/20 0.46
▸ MAPT P10636 4/20 0.45
▸ CYP1A2 P05177 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30422118 1.00 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL2124075 0.88 ALDH1A1 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL2124073 0.88 ALDH1A1 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3439635 0.82 HDAC3 (0.69) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3439636 0.82 HDAC3 (0.69) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18315880 0.80 CYP3A4 (0.49) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1357415 0.78 ALDH1A1 (0.54) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL12148878 0.77 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL13689262 0.77 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL10872471 0.77 ALDH1A1 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270158-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2025-08-28 — — US disclosed
US-12275696-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2025-04-15 — — US disclosed
CN-111511357-B Process for preparing tazicar 德玛万科学有限责任公司 2024-04-09 — — CN disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-11597692-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2023-03-07 — — US disclosed
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-06-03 — — US disclosed
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-06-03 — — US disclosed
US-10961175-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2021-03-30 — — US disclosed
US-10961175-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2021-03-30 — — US disclosed
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-01-28 — — US disclosed
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-01-28 — — US disclosed
US-10647649-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2020-05-12 — — US disclosed
US-10647649-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2020-05-12 — — US disclosed
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2019-05-16 — — US disclosed
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2019-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-10961175-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-10647649-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-12275696-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-20250270158-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885
US-11597692-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 HDAC3 2476/4885HDAC4 3668/4885HDAC1 3754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.