Sugi Predict

Sugi Predict / Compounds / SCHEMBL20972768

SCHEMBL20972768

SCHEMBL20972768

COC(=O)CC(/C=C/c1ccccc1)CC(=O)CC(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 3/20 0.41
▸ CNR2 P34972 1/20 0.39
▸ CYP1A2 P05177 2/20 0.38
▸ KCNA5 P22460 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ LMNA P02545 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ POLB P06746 1/20 0.36
▸ HDAC3 O15379 1/20 0.36
▸ HDAC4 P56524 1/20 0.36
▸ HDAC1 Q13547 1/20 0.36
▸ HDAC7 Q8WUI4 1/20 0.36
▸ HDAC2 Q92769 1/20 0.36
▸ HDAC10 Q969S8 1/20 0.36
▸ HDAC11 Q96DB2 1/20 0.36
▸ HDAC8 Q9BY41 1/20 0.36
▸ HDAC6 Q9UBN7 1/20 0.36
▸ HDAC9 Q9UKV0 1/20 0.36
▸ HDAC5 Q9UQL6 1/20 0.36
▸ HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30903492 0.86 CYP1A2 (0.41) TDP1CNR2CYP1A2ALDH1A1LMNA
SCHEMBL20972771 0.86 CYP1A2 (0.41) TDP1CNR2CYP1A2ALDH1A1LMNA
SCHEMBL23430575 0.85 TDP1 (0.38) TDP1CNR2CYP1A2ALDH1A1LMNA
SCHEMBL25611402 0.81 CYP1A2 (0.43) TDP1CNR2CYP1A2LMNAHPGD
SCHEMBL13959564 0.80 TDP1 (0.47) TDP1CNR2CYP1A2KCNA5ALDH1A1
SCHEMBL25611445 0.77 ALDH1A1 (0.41) TDP1ALDH1A1LMNAHPGDMAPT
SCHEMBL24575249 0.77 MEN1 (0.50) CYP1A2ALDH1A1LMNAHPGDPOLB
SCHEMBL7380994 0.74 KMT2A (0.43) TDP1CNR2CYP1A2ALDH1A1LMNA
SCHEMBL7377743 0.74 KMT2A (0.43) TDP1CNR2CYP1A2ALDH1A1LMNA
SCHEMBL20972782 0.73 CYP1A2 (0.44) TDP1CNR2CYP1A2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270158-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2025-08-28 — — US disclosed
US-12275696-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2025-04-15 — — US disclosed
CN-111511357-B Process for preparing tazicar 德玛万科学有限责任公司 2024-04-09 — — CN disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-11597692-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2023-03-07 — — US disclosed
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-06-03 — — US disclosed
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-06-03 — — US disclosed
US-10961175-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2021-03-30 — — US disclosed
US-10961175-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2021-03-30 — — US disclosed
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-01-28 — — US disclosed
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-01-28 — — US disclosed
EP-3706725-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2020-09-16 — — EP disclosed
CN-111511357-A Process for the preparation of talofu 德玛万科学有限责任公司 2020-08-07 — — CN disclosed
US-10647649-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2020-05-12 — — US disclosed
US-10647649-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2020-05-12 — — US disclosed
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2019-05-16 — — US disclosed
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2019-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-10961175-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-10647649-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-12275696-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-20250270158-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885
US-11597692-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 TDP1 678/4885CNR2 4009/4885CYP1A2 134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.