Sugi Predict

Sugi Predict / Compounds / SCHEMBL20972778

SCHEMBL20972778

SCHEMBL20972778

CCOC(=O)C(C(=O)OCC)C(/C=C/c1ccccc1)CC(=O)CC(C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.42
▸ KDM4E B2RXH2 3/20 0.42
▸ HPGD P15428 2/20 0.42
▸ GLA P06280 1/20 0.42
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ CTDSP1 Q9GZU7 1/20 0.41
▸ RAB9A P51151 3/20 0.40
▸ NPC1 O15118 2/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ LMNA P02545 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ MAPT P10636 2/20 0.39
▸ ADORA3 P0DMS8 1/20 0.39
▸ XBP1 P17861 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ MMP8 P22894 2/20 0.38
▸ PIN1 Q13526 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20972779 1.00 ALDH1A1 (0.42) ALDH1A1KDM4EHPGDGLAMEN1
SCHEMBL22401206 0.88 TDP1 (0.44) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL22401207 0.88 TDP1 (0.44) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL20972774 0.86 CYP1A2 (0.35) ALDH1A1LMNAPPARG
SCHEMBL20972773 0.86 CYP1A2 (0.35) ALDH1A1LMNAPPARG
SCHEMBL20972780 0.85 CYP1A2 (0.44) ALDH1A1HPGDGLALMNA
SCHEMBL20972782 0.85 CYP1A2 (0.44) ALDH1A1HPGDGLALMNA
SCHEMBL20998558 0.84 ALDH1A1 (0.39) ALDH1A1KDM4EHPGDGLAMEN1
SCHEMBL22401208 0.83 TDP1 (0.42) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL28437449 0.83 TDP1 (0.42) ALDH1A1KDM4EMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12275696-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2025-04-15 — — US disclosed
CN-111511357-B Process for preparing tazicar 德玛万科学有限责任公司 2024-04-09 — — CN disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2023-06-08 — — US disclosed
US-11597692-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2023-03-07 — — US disclosed
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-06-03 — — US disclosed
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-06-03 — — US disclosed
US-10961175-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2021-03-30 — — US disclosed
US-10961175-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2021-03-30 — — US disclosed
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-01-28 — — US disclosed
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2021-01-28 — — US disclosed
EP-3706725-A1 PROCESS FOR PREPARING TAPINAROF Dermavant Sciences GmbH (CH) 2020-09-16 — — EP disclosed
CN-111511357-A Process for the preparation of talofu 德玛万科学有限责任公司 2020-08-07 — — CN disclosed
US-10647649-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2020-05-12 — — US disclosed
US-10647649-B2 Process for preparing tapinarof Dermavant Sciences GmbH (CH) 2020-05-12 — — US disclosed
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2019-05-16 — — US disclosed
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF DERMAVENT SCIENCES GMBH (CH) 2019-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024442-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-20210163388-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-20230174445-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-10961175-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-10647649-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-12275696-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-20190144367-A1 PROCESS FOR PREPARING TAPINAROF TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885
US-11597692-B2 Process for preparing tapinarof TALDO1, TTR, CYP8B1 ALDH1A1 352/4885KDM4E 3432/4885HPGD 1101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.