Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20973071 | 0.85 | MAPT (0.40) | SMPD1MAPTTDP1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL30752530 | 0.85 | MAPT (0.40) | SMPD1MAPTTDP1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL30752529 | 0.85 | MAPT (0.40) | SMPD1MAPTTDP1NPC1RAB9A | |
| SCHEMBL22197258 | 0.84 | SMPD1 (0.46) | SMPD1SPHK1MAPTTDP1NPC1 | |
| SCHEMBL22614230 | 0.83 | HRH3 (0.35) | SMPD1SPHK1MAPTNPC1RAB9A | |
| SCHEMBL22990468 | 0.81 | SMPD1 (0.46) | SMPD1SPHK1MAPTTDP1NPC1 | |
| SCHEMBL20973058 | 0.80 | SMPD1 (0.50) | SMPD1SPHK1MAPTPPARGPPARD | |
| SCHEMBL19577736 | 0.79 | ATF4 (0.61) | SMPD1SPHK1NPC1RAB9ATSHR | |
| SCHEMBL20973047 | 0.78 | MAPT (0.51) | SMPD1MAPTTDP1NPC1RAB9A | |
| SCHEMBL27044049 | 0.77 | SMPD1 (0.43) | SMPD1SPHK1MAPTTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250115563-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2025-04-10 | — | — | US | disclosed |
| EP-3704098-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2024-01-24 | — | — | EP | disclosed |
| US-20230144871-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2023-05-11 | — | — | US | disclosed |
| US-20210113532-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2021-04-22 | — | — | US | disclosed |
| EP-3778575-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10864196-B2 | Modulators of the integrated stress pathway | CALICO LIFE SCIENCES, LLC (US) | 2020-12-15 | — | — | US | disclosed |
| US-20200361881-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-19 | — | — | US | disclosed |
| EP-3704098-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3452454-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20190142806-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142806-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | SMPD1 4033/4885SPHK1 1914/4885MAPT 3293/4885 |
| US-20230144871-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | SMPD1 4033/4885SPHK1 1914/4885MAPT 3293/4885 |
| US-20210113532-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | SMPD1 4033/4885SPHK1 1914/4885MAPT 3293/4885 |
| US-20200361881-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | SMPD1 4033/4885SPHK1 1914/4885MAPT 3293/4885 |
| US-10864196-B2 | Modulators of the integrated stress pathway | ATF4, ATF1, DDIT3 | SMPD1 4033/4885SPHK1 1914/4885MAPT 3293/4885 |
| US-20250115563-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | SMPD1 4033/4885SPHK1 1914/4885MAPT 3293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.