Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.34 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27082137 | 0.99 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL29521535 | 0.86 | MEN1 (0.49) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL29385536 | 0.85 | KMT2A (0.43) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL8752790 | 0.84 | NPC1 (0.41) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL28831144 | 0.83 | NPC1 (0.35) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL28191790 | 0.82 | NPC1 (0.39) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL29387123 | 0.82 | MAPT (0.34) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL28069714 | 0.81 | FABP5 (0.45) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL28031978 | 0.80 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL30679137 | 0.80 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161876-B2 | Anti-inflammatory nanofibers | NORTHWESTERN UNIVERSITY (US) | 2021-11-02 | — | — | US | disclosed |
| US-10905750-B2 | GRP78 antagonist that block binding of receptor tyrosine kinase orphan receptors as immunotherapy anticancer agents | Davidson, Donald J. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20190142913-A1 | GRP78 ANTAGONIST THAT BLOCK BINDING OF RECEPTOR TYROSINE KINASE ORPHAN RECEPTORS AS IMMUNOTHERAPY ANTICANCER AGENTS | CREATIVE BIOTHERAPEUTICS, LLC | 2019-05-16 | — | — | US | disclosed |