Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 6/20 | 0.69 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.69 |
| ▸ | MMP2 | P08253 | 2/20 | 0.59 |
| ▸ | MMP9 | P14780 | 2/20 | 0.59 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.56 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.56 |
| ▸ | ITGAV | P06756 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20975485 | 1.00 | ITGB1 (0.69) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL19426733 | 1.00 | ITGB1 (0.69) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL19412234 | 1.00 | ITGB1 (0.69) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL8249123 | 1.00 | ITGB1 (0.69) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL8246390 | 0.91 | ITGB1 (0.61) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL6400260 | 0.90 | GAA (0.58) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL6400256 | 0.90 | GAA (0.58) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL19426636 | 0.89 | ITGB1 (0.59) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL19426633 | 0.89 | ITGB1 (0.59) | ITGB1ITGA5MMP2MMP9FKBP1A | |
| SCHEMBL2879404 | 0.87 | ITGB1 (0.77) | ITGB1ITGA5MMP2MMP9FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10836720-B2 | Inhibitors of integrin alpha 5 beta 1 and methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-11-17 | — | — | US | disclosed |
| US-20190144386-A1 | INHIBITORS OF INTEGRIN ALPHA 5 BETA 1 AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144386-A1 | INHIBITORS OF INTEGRIN ALPHA 5 BETA 1 AND METHODS OF USE | ITGA5, ITGB5, ITGB1 | ITGB1 3/4885ITGA5 1/4885MMP2 640/4885 |
| US-10836720-B2 | Inhibitors of integrin alpha 5 beta 1 and methods of use | ITGA5, ITGB5, ITGB1 | ITGB1 3/4885ITGA5 1/4885MMP2 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.