Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.57 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.57 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | HPN | P05981 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6400260 | 1.00 | GAA (0.58) | GAAHPGDITGB1ITGA5ITGA4 | |
| SCHEMBL6710949 | 0.91 | GAA (0.60) | GAAHPGDITGB1ITGA5ITGA4 | |
| SCHEMBL19426733 | 0.90 | ITGB1 (0.69) | GAAITGB1ITGA5ITGA4FKBP1A | |
| SCHEMBL20975486 | 0.90 | ITGB1 (0.69) | GAAITGB1ITGA5ITGA4FKBP1A | |
| SCHEMBL20975485 | 0.90 | ITGB1 (0.69) | GAAITGB1ITGA5ITGA4FKBP1A | |
| SCHEMBL8249123 | 0.90 | ITGB1 (0.69) | GAAITGB1ITGA5ITGA4FKBP1A | |
| SCHEMBL19412234 | 0.90 | ITGB1 (0.69) | GAAITGB1ITGA5ITGA4FKBP1A | |
| SCHEMBL5488119 | 0.89 | GAA (0.56) | GAAHPGDITGB1ITGA5ITGA4 | |
| SCHEMBL6157865 | 0.89 | MAPK1 (0.57) | GAAHPGDITGA4FKBP1AL3MBTL1 | |
| SCHEMBL6157875 | 0.89 | MAPK1 (0.57) | GAAHPGDITGA4FKBP1AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143391-A1 | Heterocyclic amides with alpha-4 integrin antagonist activity | J. Uriach Y Compañia S.A. (ES) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143391-A1 | Heterocyclic amides with alpha-4 integrin antagonist activity | ITGB4, ITGA4, ITGA1 | GAA 2218/4885HPGD 1642/4885ITGB1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.